TABLE 3.

Adverse Events After Onset of Treatment, Related or Unrelated

		Laboratory-based AEs
		Hematology								Kidney		Liver						Pancreatobiliary
		WBCs		ANC		Hb		PLTs		sCr		T Bil		AST		ALT		GGT		ALP		Amylase		New G3/G4 AE (laboratory)
Patient no.	General	B	F	B	F	B	F	B	F	B	F	B	F	B	F	B	F	B	F	B	F	B	F
1	Acute respiratory distress, tumor-related (G5)	—	—	—	—	G3	G2	—	G3	—	—	—	—	—	—	—	—	G2	G1	G1	—	—	—	Yes
2	Tumor pain (G2)	—	—	—	—	—	G1	—	G1	—	—	—	—	—	—	—	—	G1	G1	G1	G1	—	—	No
3	None	—	—	—	—	—	—	—	G1	—	—	—	—	—	—	—	—	G1	G1	G1	G1	—	—	No
4	Tumor progression, (G5)	G1	G2	—	G1	G3	G3	G1	G3	—	G2	—	G3	—	G1	—	—	G1	G3	G2	G2	—	—	Yes
5	Tumor progression (G5)	—	—	—	—	G1	G2	G1	G3	—	G1	—	G2	G2	G4	G1	G4	G3	G4	G3	G3	—	—	Yes
6	Pneumonia*, tumor progression (G5)	—	—	—	—	G1	G3	G1	G3	—	G2	—	G2	—	G2	—	—	G3	—	G1	G2	—	—	Yes
7	Fever, urinary tract infection*	—	—	—	—	G1	G2	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	No
8	None	—	—	—	—	G1	—	—	—	—	—	—	—	—	—	—	—	—	G1	G1	G1	—	—	No
9	None	—	—	—	—	G1	G1	—	—	—	—	—	—	—	—	—	—	G3	G3	G2	G2	—	—	No
	Any new AE (%)	1 (11%)		1 (11%)		3 (33%)		6 (67%)		3 (33%)		3 (33%)		3 (33%)		1 (11%)		3 (33%)		1 (11%)		—
	Any new G3/G4 AE (%)	—		—		1 (11%)		4 (44%)		—		1 (11%)		1 (11%)		1 (11%)		2 (22%)		—		—

^*Relation to ⁹⁰Y-FAPI-46 was ruled out.

AE = adverse event; WBCs = white blood cells; ANC = absolute neutrophil count; Hb = hemoglobin; PLTs = platelets (thrombocytes); sCr = serum creatinine; T Bil = total bilirubin; AST = aspartate transaminase; ALT = alanine transaminase; GGT = γ-glutamyltransferase; ALP = alkaline phosphatase; B = baseline; F = follow-up.

G grade is defined as per CTCAE, version 5.0.