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. 2022 May;63(5):720–726. doi: 10.2967/jnumed.121.262485

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© 2022 by the Society of Nuclear Medicine and Molecular Imaging.

Immediate Open Access: Creative Commons Attribution 4.0 International License (CC BY) allows users to share and adapt with attribution, excluding materials credited to previous publications. License: https://creativecommons.org/licenses/by/4.0/. Details: http://jnm.snmjournals.org/site/misc/permission.xhtml.

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FIGURE 4. — A 71-y-old man with locally advanced stage III melanoma treated with pembrolizumab. Baseline CT and fused ¹⁸F-FDG PET/CT images (left) demonstrate 2 ¹⁸F-FDG–avid metastases in left axilla (SUV_MAX = 10.0, medial node; SUV_MAX = 7.6, lateral node). CT and fused CD8 PET/CT images (middle) obtained at 28 d after start of immunotherapy demonstrate increased tracer activity in both metastases (SUV_MAX = 9.5, medial node; SUV_MAX = 10.0, lateral node), suggestive of tumor infiltration by CD8+ T cells. Follow-up imaging with contrast-enhanced CT (right) demonstrated complete response to therapy.