Spirooxindoles obtained without the use of pre-synthesized acyl chloride.
| Compound # | R1 | R2 | R3 | a/b | Yields,% |
|---|---|---|---|---|---|
| 22a,b | H | 4-F | 4-Cl | 2/1 | 65 |
| 23a,b | H | 4-Cl | 4-Cl | 1.2/1 | 71 |
| 24a,b | H | 4-Br | 4-Cl | 1.5/1 | 59 |
| 25a,b | H | 4-OH | 4-Cl | — | 0 |
| 26a,b | H | 4-OEt | 4-Cl | 3.4/1 | 75 |
| 27a,b | H | 3-Cl, 4-F | 4-Cl | 5/1 | 41 |
| 28b | H | 2-F | 4-Cl | — | 32 |
| 29a,b | H | 3-F | 4-Cl | 1.5/1 | 45 |
| 30b | H | 3-Cl | 4-Cl | — | 25 |
| 31a,b | H | 3-Br | 4-Cl | 1.4/1 | 47 |
| 32a,b | H | 3-I | 4-Cl | 1.3/1 | 80 |
| 33a,b | H | 4-OMe | 4-Cl | 4.5/1 | 78 |
| 34a | H | 3-Me | 4-Cl | — | 65 |
| 35a | H | 4-Me | 4-Cl | — | 73 |
| 36a | Cl | 4-F | 4-Cl | — | 27 |
| 37a | Cl | 4-OMe | 4-Cl | — | 48 |
| 38a | Cl | 3-Me | 4-Cl | — | 58 |
| 39a | Cl | 4-Me | 4-Cl | — | 54 |
| 40a | Br | 4-F | 4-Cl | — | 51 |
| 41a | Br | 4-OMe | 4-Cl | — | 74 |
| 42a,b | Br | 3-Me | 4-Cl | 4/1 | 84 |
| 43a | H | 4-OMe | 4-Br | -/1 | 75 |