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. 2022 Apr 12;25(5):104241. doi: 10.1016/j.isci.2022.104241

Figure 4.

Figure 4

Dietary tryptophan alters the metabolism of TC CD4+ T cells

(A) Heatmap of tryptophan metabolites in CD4+ T cells from TC mice fed with high or low tryptophan for 1 month (N = 5 per group).

(B) Values from (A) shown for selected metabolites. Graphs show individual mice with mean ± SEM t tests, ∗∗p < 0.01, ∗∗p < 0.001, ∗∗∗p < 0.0001.

(C) Heatmaps of metabolites in the glycolysis/PPP and TCA cycle/OXPHOS pathways showing Log10 transformed means for each group ordered from the highest to lowest in the Trp high group (N = 5).

(D) Representation of the glycolysis/PPP pathway.

(E) Representation of the TCA cycle. In (D) and (E), the metabolites present in the heatmaps in (C) are shown in red.

(F) Top 5 CD4+ T cells most changed by high dietary tryptophan in TC mice for the tryptophan, glycolysis, and TC/OXPHOS pathways. The values show the difference between high and low tryptophan as a percentage of the low tryptophan value, all Log10-transformed, as shown in the heatmaps.