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. 2022 Apr 12;25(5):104241. doi: 10.1016/j.isci.2022.104241

Figure 5.

Figure 5

Exogenous tryptophan enhanced glycolysis and TCA cycle activity in TC CD4+ T cells in vitro

(A) Heatmaps of metabolites differentially represented between B6 and TC CD4+ T cells after 24 h activation with the addition of 50 uM tryptophan (Trp hi). Metabolites that differed between strains only at basal level of tryptophan were excluded.

(B) Heatmaps of metabolites differently represented between TC CD4+ T cells at baseline and with 50 uM tryptophan.

(C) Subsets of metabolites from A and B in the tryptophan, glycolysis, and TCA pathways.

(D) Kynurenine levels in B6 and TC CD4+ T cells after 24 h activation without or with the addition 50 uM kynurenine. Graphs show individual mice with mean ± SEM.

(E) Heatmap showing metabolites differently represented in TC and B6 T cells above and below the horizontal line respectively, with the addition of kynurenine. Data show Log10 transformed means for each group ordered from the highest to lowest in the B6 control group (N = 3 per group).