Table 2.

Adjusted time-dependent hazard ratios comparing overall and cause-specific mortality in SARS-CoV-2 cases and reference group in two age groups across different stages of follow-up, Estonia 2020-2021.

OVERALL MORTALITY
	Age <60			Age 60+
	Adjusted hazard ratio * (95% CI)	p-value	Deaths in SARS-CoV-2 cases/reference group	Adjusted hazard ratio (95% CI)	p-value	Deaths in SARS-CoV-2 cases/reference group
Early, acute period	4·7 (3·0-7·5)	<0·0001	47/28
1-10 days				20·1 (15·5-26·1)	<0·0001	402/67
11-20 days				15·5 (12·1-19·7)	<0·0001	344/80
21-35 days				7·9 (6·2-9·9)	<0·0001	219/105
Mid- and long-term	0·9 (0·7-1·2)	0·5360	81/244
36-50 days				3·9 (2·9-5·1)	<0·0001	104/104
51-84 days				2·8 (2·2-3·5)	<0·0001	130/184
85-365 days				1·7 (1·5-1·8)	<0·0001	581/1376
CAUSE-SPECIFIC MORTALITY I00-I99: DISEASES OF THE CIRCULATORY SYSTEM
Early, acute period	1·5 (0·5-5·0)	0·5038	4/8	5·4 (4·4-6·6)	<0·0001	221/144
Mid- and long-term	1·1 (0·6-2·2)	0·6730	12/33	2·1 (1·8-2·3)	<0·0001	401/748
C00-D48: NEOPLASMS
Early, acute period	4·8 (1·4-15·8)	0·0109	8/4	4·3 (3·0-6·3)	<0·0001	68/47
Mid- and long-term	1·0 (0·6-1·7)	0·9104	18/46	1·5 (1·2-1·9)	<0·0001	135/297
J00-J99: DISEASES OF THE RESPIRATORY SYSTEM
Early, acute period	(0-Inf)	0·9906	2/0	29·2 (12·5-68·3)	<0·0001	49/6
Mid- and long-term	2·0 (0·4-8·9)	0·3684	3/4	1·9 (1·2-3·0)	0·0111	23/51
OTHER CAUSES
Early, acute period	1·2 (0·5-3·2)	0·6731	6/14	5·0 (3·4-7·6)	<0·0001	55/41
Mid- and long-term	0·8 (0·5-1·3)	0·3827	27/93	1·8 (1·4-2·2)	<0·0001	117/264

*All models are adjusted for age, sex, Charlson comorbidity index and pre-index date health care utilization intensity. The models for overall mortality are additionally adjusted for the county of Estonia. (HR-s corresponding to all adjustment variables as well as sex- and age-adjusted case-control hazard ratios are provided in Online Supplement).