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. 2022 Apr 29;11(5):e1391. doi: 10.1002/cti2.1391

Figure 4.

Figure 4

Titres and neutralising activity anti‐SARS‐CoV‐2 antibodies in SOT recipients after two doses of a COVID‐19 mRNA vaccine. Titres of (a) IgG and (b) IgA antibodies against different full‐length recombinant SARS‐CoV‐2 proteins and their delta variants were measured in an ELISA after two doses of a COVID‐19 mRNA vaccine. Antibody titres are shown for healthy vaccinated controls and the three different groups of vaccinated SOT patients (Good Responders [GR], Reduced Responders [RR] and Non‐Responders [NR]) according to the degree of viral neutralisation after the second dose of the vaccine. Correlation between anti‐RBD IgG antibody titres and (c) neutralising activity in the same sample and (d) time from SOT at the time of the first dose of the vaccine. (e) Impact of steroid or antimetabolite intake on anti‐RBD IgG antibody titres after two doses of the vaccine. Bars indicate means + SD. Differences between groups were analysed for statistical significance (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001) using the Mann–Whitney U‐test.