Table 3.

Mesenchymal-epithelial transition factor inhibitors

Drug	MET-specific	Type	Other targets	IC50 (nmol/L)
Crizotinib	No	Ia	ALK, ROS1	22.5
Capmatinib	Yes	Ib	--	0.6
Tepotinib	Yes	Ib	--	3
Salovitinib	Yes	Ib	--	2.1
Bozitinib	Yes	I	--	0.51
Cabozantinib	No	II	RET, ROS1, VEGFR2, KIT	7.8
Merestinib	No	II	TIE-1, AXL, ROS1, DDR1/2, FLT3, MERTK, RON	8.1
Glesatinib	No	II	MET, VEGFR, RON, TIE-2	21.1

IC50: Half maximal inhibitory concentration; MET: Mesenchymal-epithelial transition factor.