Skip to main content
. 2022 Mar 26;298(5):101870. doi: 10.1016/j.jbc.2022.101870

Figure 6.

Figure 6

Dynamic interconversion of the TOM complex for selective substrate import. Photo-activated crosslinking revealed a dynamic interconversion of the dimeric and trimeric states of the TOM–CC for import of Cys-rich proteins into the IMS and precursors through Tim50–TIM23, respectively. Mitochondrial porin binds and sequesters Tom22, triggering dissociation of the trimeric state. Phosphorylation of Tom6 favors the trimeric assembly. Figure inspired from (50). IMS, intermembrane space; TIM, translocase of the inner mitochondrial membrane; TOM, translocase of the outer mitochondrial membrane; TOM–CC, TOM core complex.