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. 2022 Apr 13;14(16):18016–18030. doi: 10.1021/acsami.1c22280

Figure 6.

Figure 6

Lubricin subjected to accelerated aging conditions still exhibited antiadhesive properties on StcE-treated differentiated hTCEpi cells. Supplementation with unstressed recombinant human lubricin (A) and lubricin subjected to temperature stress (B), acid stress (C), or alkaline stress (D) reduced the adhesion of CellTracker Deep Red-labeled HCjE cells in suspension to StcE-treated hTCEpi cells (data = mean ± SD, n = 4). (E) Subjecting lubricin to accelerated aging conditions resulted in more variable antiadhesive properties. Statistical significance (p < 0.05) was determined using one-way Welch's ANOVA with post-hoc Dunnett’s T3 multiple comparisons testing relative to StcE-treated (0 μg/mL) cells (A–D) or unstressed drug substance (DS) (E).