Table 3.
Association of clinical features with expression of markers in the studied population (N = 61)
| Factor | CK19 | p-value | OCT4 | p-value | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Negative, n = 23 | Positive, n = 38 | Negative, n = 24 | Positive, n = 37 | ||||||||
| n | % | n | % | n | % | n | % | ||||
| Age, years (mean ± SD) | 45.5 ± 11.8 | 49.5 ± 8.1 | 0.124 | 51 ± 9.8 | 0.053 | ||||||
| Menopausal status | Pre | 13 | 56.50 | 14 | 36.80 | 0.134 | 9 | 37.50 | 18 | 48.60 | 0.392 |
| Post | 10 | 43.50 | 24 | 63.20 | 15 | 62.50 | 19 | 51.40 | |||
| Body mass index (BMI) | Low | 4 | 17.40 | 7 | 18.40 | 0.919 | 1 | 4.20 | 10 | 27.00 | 0.023 |
| High | 19 | 82.60 | 31 | 81.60 | 23 | 95.80 | 27 | 73.00 | |||
| Family history | No | 22 | 95.70 | 33 | 86.80 | 0.263 | 23 | 95.80 | 32 | 86.50 | 0.231 |
| Yes | 1 | 4.30 | 5 | 13.20 | 1 | 4.20 | 5 | 13.50 | |||
| Diabetes mellitus (DM) | No | 20 | 87.00 | 32 | 84.20 | 0.769 | 21 | 87.50 | 31 | 83.80 | 0.689 |
| Yes | 3 | 13.00 | 6 | 15.80 | 3 | 12.50 | 6 | 16.20 | |||
| Pathological types | IDC | 16 | 69.60 | 24 | 63.20 | 0.39 | 15 | 62.50 | 25 | 67.60 | 0.153 |
| IL | 6 | 26.10 | 8 | 21.10 | 8 | 33.30 | 6 | 16.20 | |||
| Others | 1 | 4.30 | 6 | 15.80 | 1 | 4.20 | 6 | 16.20 | |||
| Grade | 1 | 3 | 13.00 | 1 | 2.60 | 0.002 | 3 | 12.50 | 1 | 2.70 | 0.063 |
| 2 | 16 | 69.60 | 13 | 34.20 | 14 | 58.30 | 15 | 40.50 | |||
| 3 | 4 | 17.40 | 24 | 63.20 | 7 | 29.20 | 21 | 56.80 | |||
| Capsular invasion | No | 14 | 60.90 | 21 | 55.30 | 0.668 | 14 | 58.30 | 21 | 56.80 | 0.903 |
| Yes | 9 | 39.10 | 17 | 44.70 | 10 | 41.70 | 16 | 43.20 | |||
| OR | Negative | 7 | 30.40 | 19 | 50.00 | 0.134 | 6 | 25.00 | 20 | 54.10 | 0.025 |
| Positive | 16 | 69.60 | 19 | 50.00 | 18 | 75.00 | 17 | 45.90 | |||
| PR | Negative | 11 | 47.80 | 20 | 52.60 | 0.716 | 10 | 41.70 | 21 | 56.80 | 0.249 |
| Positive | 12 | 52.20 | 18 | 47.40 | 14 | 58.30 | 16 | 43.20 | |||
| HER2 | Negative | 21 | 91.30 | 23 | 60.50 | 0.009 | 18 | 75.00 | 26 | 70.30 | 0.687 |
| Positive | 2 | 8.70 | 15 | 39.50 | 6 | 25.00 | 11 | 29.70 | |||
| KI 67 | Low | 19 | 82.60 | 25 | 65.80 | 0.156 | 18 | 75.00 | 26 | 70.30 | 0.687 |
| High | 4 | 17.40 | 13 | 34.20 | 6 | 25.00 | 11 | 29.70 | |||
| Molecular subtypes | Luminal A | 16 | 69.60 | 8 | 21.10 | < 0.001 | 15 | 62.50 | 9 | 24.30 | 0.019 |
| Luminal B | 0 | 0.00 | 11 | 28.90 | 3 | 12.50 | 8 | 21.60 | |||
| HER2 amplified | 2 | 8.70 | 12 | 31.60 | 2 | 8.30 | 12 | 32.40 | |||
| Triple -ve | 5 | 21.70 | 7 | 18.40 | 4 | 16.70 | 8 | 21.60 | |||
| T | 0 | 1 | 4.30 | 1 | 2.60 | 0.126 | 1 | 4.20 | 1 | 2.7 | 0.63 |
| 1 | 5 | 21.70 | 4 | 10.50 | 4 | 16.70 | 5 | 13.50 | |||
| 2 | 5 | 17.40 | 5 | 13.20 | 2 | 8.30 | 8 | 21.60 | |||
| 3 | 10 | 43.50 | 13 | 34.20 | 11 | 45.80 | 12 | 32.40 | |||
| 4 | 2 | 8.70 | 15 | 39.50 | 6 | 25.00 | 11 | 29.70 | |||
| N | 0 | 9 | 39.10 | 1 | 2.60 | < 0.001 | 7 | 29.20 | 3 | 8.10 | 0.017 |
| 1 | 9 | 39.10 | 8 | 21.10 | 9 | 37.50 | 8 | 21.60 | |||
| 2 | 4 | 17.40 | 1 | 2.60 | 0 | 0.00 | 5 | 13.50 | |||
| 3 | 1 | 4.30 | 28 | 73.70 | 8 | 33.30 | 21 | 56.80 | |||
| M | No | 21 | 91.30 | 25 | 65.80 | 0.026 | 22 | 91.70 | 24 | 64.80 | 0.018 |
| Yes | 2 | 8.70 | 13 | 34.20 | 2 | 8.30 | 13 | 35.10 | |||
| Stage | Stage I | 3 | 13.00 | 1 | 2.60 | 0.001 | 2 | 8.30 | 2 | 5.40 | 0.066 |
| Stage II | 10 | 43.50 | 3 | 7.90 | 8 | 33.30 | 5 | 13.50 | |||
| Stage III | 8 | 34.80 | 21 | 55.30 | 12 | 50.00 | 17 | 45.90 | |||
| Stage IV | 2 | 8.70 | 13 | 34.20 | 2 | 8.30 | 13 | 35.10 | |||