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. 2021 Aug 20;122(8):7269–7326. doi: 10.1021/acs.chemrev.1c00212

Figure 22.

Figure 22

Characterization of wild-type EPO and 23 glycoengineered EPO variants by high-resolution native MS. (A) Illustrative deconvoluted native mass spectra of WT EPO (top) and the knockout-based glycoengineered clones C23 (middle) and C21 (bottom). (B) Comparison of native mass spectra of EPO from two biological replicate clones C22 (black) and C24 (orange) by correlation scoring. (C) Clustering of the glycoengineered EPO clones based on the correlation between their native MS spectra. From ref (381). CC BY 4.0.