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. 2022 Mar 23;11(4):415–433. doi: 10.1093/stcltm/szac008

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© The Author(s) 2022. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — Single-cell RNA-Seq of RB1 patient-specific iPSC-derived retinal organoids. UMAPs showing the cell clusters in control (RB1^+/+), heterozygous (RB1^+/-) and homozygous (RB1^−/−) organoids (A) and cell cycle distribution (B). (C) UMAP of integrated control (RB1^+/+), heterozygous (RB1^+/-) and homozygous (RB1^−/−) organoids with cell cluster annotations. Cluster 17 was exempted from analysis because of low read number. (D) Percentages of cells in each cell cluster of control RB1^+/+, RB1^+/- and RB1^−/− organoids. (E) UMAPS with overlays of representative marker gene expression.