Figure 3.

Time scale and specificity of different ion activation methods. Slow heating methods involve multiple activation events, leading to the cleavage of labile chemical bonds. Fast energy deposition occurs in a single activation step and yields complementary, site-specific fragments. UVPD = ultraviolet photodissociation; ExD = electron-mediated dissociation (including ECD, ETD, EDD, and EID/EED); HCD = higher-energy collisional dissociation; EThcD = electron-transfer/higher-energy collision dissociation; a-EPD = activated electron photodetachment; IRMPD = infrared multiple photon dissociation; CID = collision-induced dissociation.