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. 2021 Sep 7;122(8):7840–7908. doi: 10.1021/acs.chemrev.1c00380

Figure 4.

Figure 4

Influence of ion polarity and the ion activation method on the fragmentation pattern of N-glycans. (A) CID in positive ion mode mainly yields B-fragments from glycosidic cleavage. The abundance of cross-ring fragments can be increased by the coordination of metal cations (B) or by employing CID in negative ion mode (C). Figure reprinted with permission from ref (95). 2020 Copyright Wiley-VCH. (D) ECD yields both glycosidic and cross-ring cleavage. Figure adapted with permission from ref (85). Copyright 2007 American Chemical Society. (E) UVPD of N-glycans yields a wealth of fragments, which are informative but challenging to interpret. Only cross-ring fragments are shown in the accompanying structure for clarity. Figure adapted with permission from ref (76). Copyright 2011 American Chemical Society.