Table 1.
Effects of high fat diet consumption on the cardiometabolic parameters of WT or TLR4-mut mice
| Parameters | WT | TLR4-mut | ||
|---|---|---|---|---|
| ND | HFD | ND | HFD | |
| Body weight (g) | 38 ± 1 | 41 ± 0.8 | 36 ± 0.7 | 39 ± 0.6 |
| Abdominal fat (g) | 1.53 ± 0.1 | 2.47 ± 0.2** | 1.7 ± 0.1 | 1.9 ± 0.1# |
| Body fat (%) | 35.6 ± 1.4 | 47.2 ± 1.5** | 37.5 ± 2.9 | 43.3 ± 1.2 |
| SBP (mmHg) | 94.5 ± 1.3 | 151.4 ± 2.4* | 94.1 ± 2.5 | 98.7 ± 2.9# |
| Fasting glucose (mg/dl) | 101.3 ± 13.5 | 170.9 ± 10.7** | 122.7 ± 8.2 | 129.6 ± 7.5# |
| Fasting insulin (ng/ml) | 0.21 ± 0.1 | 0.67 ± 0.3* | 0.29 ± 0.7 | 0.26 ± 0.7# |
| HOMA-IR | 1.51 ± 0.7 | 7.82 ± 3.7* | 2.57 ± 0.7 | 2.43 ± 0.7# |
| Total cholesterol (mg/dl) | 120.1 ± 18.1 | 180.2 ± 12.2* | 140.4 ± 15.6 | 139.9 ± 6.3# |
| Triglycerides (mg/dl) | 59.2 ± 7.9 | 264.6 ± 29.2*** | 47.2 ± 6.4 | 58.4 ± 4.7### |
SBP systolic blood pressure, HOMA-IR homeostatic model assessment. Values represent the mean ± SEM of 8–12 animals per group. *p < 0.05, **p < 0.01, ***p < 0.001 vs. WT-ND, and #p < 0.05 and ###p < 0.001 vs. WT-HFD