Table 5.
Prognostic model based on SIRI and NLR for GBM patients
| Clinical variables | Prognostic models | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Original cohort (model SIRI) | Original cohort (model NLR) | PSM cohort (model SIRI) | PSM cohort (model NLR) | ||||||||||
| HR | 95% CI | p value | HR | 95% CI | p value | HR | 95% CI | p value | HR | 95% CI | p value | ||
| Age at diagnosis | < 55 | Reference | – | – | Reference | – | – | Reference | – | – | Reference | – | – |
| ≥ 55 | 1.314 | 1.011–1.707 | 0.041 | 1.340 | 1.032–1.740 | 0.028 | 1.441 | 1.042–1.993 | 0.027 | 1.516 | 1.099–2.090 | 0.011 | |
| Gender | Male | Reference | – | – | Reference | – | – | – | – | – | – | – | – |
| Female | 0.699 | 0.528–0.925 | 0.012 | 0.618 | 0.473–0.807 | < 0.001 | – | – | – | – | – | – | |
| Adjuvant therapy | Yes | Reference | – | – | Reference | – | – | Reference | – | – | Reference | – | – |
| No or undone | 2.151 | 1.587–2.916 | < 0.001 | 2.139 | 1.569–2.914 | < 0.001 | 1.685 | 1.158–2.451 | 0.006 | 1.511 | 1.030–2.216 | 0.035 | |
| Ki67 | < 30% | Reference | – | – | Reference | – | – | – | – | – | – | – | – |
| ≥ 30% | 1.316 | 1.019–1.699 | 0.036 | 1.274 | 0.988–1.644 | 0.062 | – | – | – | – | – | – | |
| IDH-1 | Mutant | Reference | – | – | Reference | – | – | Reference | – | – | Reference | – | – |
| Wildtype | 2.384 | 1.560–3.643 | < 0.001 | 2.404 | 1.575–3.668 | < 0.001 | 2.958 | 1.729–5.063 | < 0.001 | 2.837 | 1.658–4.855 | < 0.001 | |
| SIRI | Low | Reference | – | – | – | – | – | Reference | – | – | – | – | – |
| High | 1.646 | 1.253-2.163 | < 0.001 | – | – | – | 1.641 | 1.206–2.234 | 0.002 | – | – | – | |
| NLR | Low | – | – | – | Reference | – | – | – | – | – | Reference | – | – |
| High | – | – | – | 1.392 | 1.013–1.912 | 0.041 | – | – | – | 1.601 | 1.132–2.265 | 0.008 | |
| C-index | 0.672 | 0.659 | 0.656 | 0.650 | |||||||||
| AIC | 2410.09 | 2418.68 | 1516.63 | 1518.11 | |||||||||
Significant findings are expressed in bold and italic
Abbreviations: HR hazard ratio, CI confidence interval, IDH-1 isocitrate dehydrogenase-1, SIRI systemic inflammation response index, NLR neutrophil to lymphocyte ratio, PSM propensity score matching, C-index Harrell’s concordance index, AIC Akaike information criterion