Fig. 3.

An overview of exosomes/exosomal cargo contents in the regulation of cancer radiosensitivity. Exosomes/exosomal cargo contents exert important function to regulate the radiosensitivity of cancer cells, via complicate interaction with multiple biological processes including DNA damage response, cell cycle and apoptosis, hypoxic tumor microenvironment, epithelial–mesenchymal transition, cancer stem cells and radiation-induced signaling pathways