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. 2022 Apr 29;14:45. doi: 10.1186/s13073-022-01050-w

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Development and description of stemness signature. A Circos plot depicting the development of Stem.Sig. B Pathway enrichment analysis of genes in Stem.Sig. The bar plot showed the top 20 enriched Reactome pathways. The cnetplot presented the network of specific genes from these pathways. Colored points referred to the corresponding pathways. Abbreviation: CFTR, cystic fibrosis transmembrane conductance regulator; GG-NER, global genomic nucleotide excision repair; HIF, hypoxia-inducible factor; PCP, planar cell polarity; CE, convergent extension