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. 2022 Apr 28;23:104. doi: 10.1186/s12931-022-02024-7

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — IR actives BCL6 which regulates miR-486-3p transcription. A Detection of pri-miR-486-3p expression at different time after irradiation of both cells using qRT-PCR. B Detection of BCL6 mRNA expression at different time after irradiation using qRT-PCR. C Changes of transcription factor BCL6 protein levels at different time after irradiation. D, E Changes of pri-miR-486-3p and miR-486-3p after overexpress BCL6 in both cells. F Schematic diagram of the binding site of BCL6 and miR-486-3p promoter region. G Dual luciferase reporter system validates the binding site. *p < 0.05