Fig. 7.

BCL 6 mediates RIPF via miR-486-3p/Snail Axis. A Mice were divided into four groups: Normal (Nor), irradiated alone (IR), irradiated after lung administration (AAV + NC, IR + NC), irradiated after lung administration (AAV + mimic, IR + mimic). B miR-486-3p levels in irradiated mouse lung tissue (n = 5) at different time using qRT-PCR. C, D H&E staining (n = 5) and the score of lung tissue, scale bar, 100 µm. E Masson’s staining (n = 5) and the Relative content quantitation of Collagen. G Alterations of pulmonary fibrosis-related protein levels in lung tissue after 4 months of irradiation. On the right, the bar graph shows the gray value analysis. H Changes in transcription factor BCL6 and target proteins in different groups after irradiation. I Snail expression in lung tissues by immunohistochemical experiment. J Quantitative analysis of IHC (n=5). *p < 0.05 compared with Normal; ^#p < 0.05 compared with IR + NC