. 2022 Mar 22;144(16):7072–7079. doi: 10.1021/jacs.2c01735

Table 1. Reaction Optimization^a.

entry	variation from the standard condition	yield of 3a (%)^b
1	none	73 (70)^c
2	Ru(bpy)₃(PF₆)₂ instead of Ir–F	ND
3	9-Mesityl-10-methylacridinium instead of Ir–F	ND
4	CH₃CN instead of CH₃CN/DMF	50
5	CH₃CN/Acetone instead of CH₃CN/DMF	61
6	Cs₂CO₃ instead of K₂HPO₄	40
7	NHC B instead of NHC A	2
8	NHC C instead of NHC A	35
9	NHC D instead of NHC A	ND
10	no light irradiation	ND
11	no NHC catalyst	ND
12	no photocatalyst	ND

Reaction conditions: 1a (0.1 mmol), 2a (0.4 mmol), NHC A (20 mol %), Ir–F (2 mol %), K₂HPO₄ (2.0 equiv), and CH₃CN/DMF (1 mL/0.1 mL) under irradiation with 5 W blue LEDs for 24 h, 15:1 d.r.

Yields were determined by ¹H NMR using 1,3,5-trimethoxybenzene as internal standard.

Isolated yield in brackets. ND = not detected.

Table 1. Reaction Optimizationa.

Table 1. Reaction Optimization^a.