Phase I metabolites of INF identified in MS and MS2 scans.
| MS scan | Major daughter ions | t R (min) | Proposed metabolic reaction | |
|---|---|---|---|---|
| INF | 560 | 339, 313 | 31.8 | INF + H |
| M1 | 576 | 559, 329, 312, 205 | 33.7 | α Hydroxylation at piperazine ring |
| M2 | 546 | 528, 339, 313 | 31.7 | O-Demethylation |
| M3 | 532 | 311, 285 | 35.1 | N-Dealkylation |
| M4 | 510 | 492, 325 | 24.6 | Dechlorination of two chlorine groups then hydroxylation and N-demethylation |
| M5 | 528 | 510, 313 | 20.2 | Dechlorination of one chlorine group then hydroxylation and O-dealkylation |
| M6 | 542 | 340, 313 | 20.7 | Dechlorination of one chlorine group then hydroxylation |
| M7 | 524 | 506, 312 | 29.1 | Dechlorination of two chlorine groups then hydroxylation |