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. Author manuscript; available in PMC: 2022 Apr 29.
Published in final edited form as: J Med Chem. 2020 Nov 4;63(22):13878–13898. doi: 10.1021/acs.jmedchem.0c01475

Scheme 3.

Scheme 3

Reagents and conditions: (a) N, O-dimethylhydroxylamine HCl salt, BOP, Et3N (62%–83%); (b) for 42 or 43: LiAlH4 (77%–88%); (c) for 44: Cp2Zr(H)Cl (56%); (d) 34, NaBH4 (48%–57%); (e) TFA/H2O (9:1) (59%–65%).