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. Author manuscript; available in PMC: 2022 Apr 29.
Published in final edited form as: J Med Chem. 2020 Nov 4;63(22):13878–13898. doi: 10.1021/acs.jmedchem.0c01475

Figure 5:

Figure 5:

Active site cavityi of the hPNMT-3+11 complex57 (gray) [PDB: 2G70, Chain B] showing co-substrate 3 and inhibitor 11. Labeled amino acids have been shown by site directed mutagenesis to interact with the substrate or co-substrate.51,54 Carbon is shown in white, nitrogen in blue, oxygen in red and sulfur in yellow. Hydrogens are not shown for clarity.

i PyMOL Molecular Graphics System, Version 2.1c, Schrödinger, LLC.