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. Author manuscript; available in PMC: 2022 Apr 29.
Published in final edited form as: J Med Chem. 2020 Nov 4;63(22):13878–13898. doi: 10.1021/acs.jmedchem.0c01475

Figure 6.

Figure 6.

Active site cavity58 (gray) from the hPNMT-3+1157 crystal structure [PDB: 2G70]. Amino acids used in the site-directed mutagenesis investigations are labeled. A molecule of Tris was identified in both hPNMT:bisubstrate inhibitor complexes. Atom colors are described in Figure 5. The Figures show (a) the potent bisubstrate inhibitor 19 that contains a four-atom amine linker [PDB: 4MIK, Chain A] and (b) the bisubstrate inhibitor 29 [PDB: 4MQ4, Chain A] that contains a five-atom length amide linker.