Fig. 10. Two-dimensional illustrations of two different binding modes of butein (A and B), isoliquiritigenin (C and D), and scopoletin (E and F) in the SIRT1 activator-binding site. The two-dimensional structures of the compounds are drawn as black lines. Interacting residues are represented as balls that are colored according to the type of interaction. A red ball indicates the residue contributing to an unfavorable interaction.
