FIG. 5.

Simulated EEG effect for the same rat as in Fig. 1 according to the effect compartment model following imipenem infusions. (A) The same dose (80 mg) administered for various durations, leads to changes in C_max but not in AUC. Lines correspond to infusions at 0 (bolus), 15, 30, 60, 90, 120, 150, and 180 min; solid lines represent experimental conditions used during this study. (B) Various rates (3.20, 2.85, 2.65, and 2.50 mg min⁻¹ for 20, 25, 30, and 35 min, respectively) lead to changes in doses (64, 71, 80, and 88 mg, respectively) and, therefore, AUC, but peak concentrations in serum (C_max = 437 μg ml⁻¹) do not change. The solid line corresponds to an experimental condition used in this study (30-min infusion).