TABLE 2.
PD parameters characteristic of imipenem infused i.v. to rats at a dose of 80 mg at various rates, derived from the compartment effect modela
| Group | Infusion rate (mg min−1) | Infusion duration (min) | Mean ± SD
|
|||
|---|---|---|---|---|---|---|
| P0∗ (mV2) | B∗ | n∗ | ke0∗ (min−1) | |||
| I (n = 6) | 2.65 | 30 | 0.21 ± 0.07 | 0.0264 ± 0.0147 | 7.1 ± 6.6 | 0.0054 ± 0.0031 |
| II (n = 6) | 1.325 | 60 | 0.16 ± 0.07 | 0.0236 ± 0.0199 | 4.5 ± 4.4 | 0.0099 ± 0.0075 |
| III (n = 6) | 0.883 | 90 | 0.18 ± 0.07 | 0.0155 ± 0.0091 | 5.1 ± 4.1 | 0.0128 ± 0.0083 |
a
∗, non-statistically significant differences between groups based on one-way ANOVA.