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. 2021 Nov 9;1:45. doi: 10.1038/s43856-021-00046-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Overview of the polygenic risk scoring approach employed. Results from a published GWAS are used to estimate the polygenic risk for a given trait in the AGDS. These scores can be used to predict the side effect of interest. b Forest plot showing the results, odds ratio (OR) and 95% (C.I.) for the association between MDD PRS and side effects across antidepressants. MDD—major depressive disorder; PRS—polygenic risk score.