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. 2022 Apr 20;2:45. doi: 10.1038/s43856-022-00107-6

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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Each histogram of cell types (HCT) is created individually for each Region of Interest (ROI) tile. The Integrated HCT (IHCT) is then updated as successive ROI histogram are accumulated. This process is stopped once the IHCT is converged using the Chi-square (χ²) distance. Collective cytological information from a patient bone marrow aspirate is then represented as an IHCT and a table with summary statistics such as the number of each cell type, percentage, BM_ME ratio and Chi-Square distance. b Variation of the Chi-square distance through visiting and analyzing selected ROI tiles by the architecture and how an IHCT is converged by processing each tile. For five samples of patients, the IHCT is converged after visiting a number of tiles in the range of 400 to 500 tiles.