Table 1.
Daytime assessments for the windowed and continuous approach.
| Windowed (ONOFF) approach | Continous (ON) approach | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Weak responder | Strong responder | Weak responder | Strong responder | |||||||||
| Sham | Verum | Sham | Verum | statistics | Sham | Verum | Sham | Verum | statistics | |||
| Mean (SEM) | Mean (SEM) | Mean (SEM) | Mean (SEM) | pcond | pcondxresp | Mean (SEM) | Mean (SEM) | Mean (SEM) | Mean (SEM) | pcond | pcondxresp | |
| Sleep questionnaire | ||||||||||||
| Sleep qualitya | 4.6 (0.34) | 4.56 (0.30) | 3.96 (0.25) | 3.87 (0.27) | 0.40 | 0.46 | 4.49 (0.33) | 4.34 (0.32) | 3.62 (0.33) | 3.91 (0.3) | 0.54 | 0.08* |
| Sleep deptha | 3.05 (0.25) | 2.96 (0.21) | 2.67 (0.16) | 2.52 (0.15) | 0.12 | 0.66 | 2.97 (0.22) | 2.76 (0.16) | 2.52 (0.11) | 2.43 (0.18) | 0.17 | 0.35 |
| MDBF | ||||||||||||
| Mood morningb | 102.11 (3.10) | 98.47 (4.52) | 100.67 (5.44) | 96.79 (5.84) | 0.021* | 0.74 | 102.68 (2.76) | 100.27 (3.82) | 98.08 (5.94) | 94.83 (6.04) | 0.011* | 0.55 |
| Mood whole dayb | 104.12 (2.45) | 96.39 (6.2) | 101.34 (4.94) | 98.99 (4.94) | 0.074* | 0.55 | 103.36 (2.7) | 103.31 (2.93) | 100.99 (5.09) | 95.36 (5.88) | 0.038* | 0.18 |
| Sleepiness | ||||||||||||
| KSS moringa | 3.09 (0.24) | 3.07 (0.20) | 3.61 (0.22) | 3.76 (0.33) | 0.77 | 0.81 | 3.01 (0.18) | 3.1 (0.19) | 3.85 (0.3) | 3.8 (0.32) | 0.98 | 0.36 |
| KSS 2pma | 3.04 (0.27) | 2.99 (0.28) | 3.29 (0.18) | 3.33 (0.39) | 0.94 | 0.71 | 3.1 (0.35) | 2.93 (0.28) | 3.21 (0.16) | 3.42 (0.27) | 0.96 | 0.48 |
| KSS eveninga | 3.3 (0.30) | 3.14 (0.18) | 3.7 (0.20) | 3.87 (0.23) | 0.41 | 0.71 | 3.38 (0.38) | 2.85 (0.23) | 3.39 (0.21) | 4.12 (0.43) | 0.57 | 0.02* |
| PVT | ||||||||||||
| Speed (1/RT)b | 3.14 (0.1) | 3.1 (0.1) | 3.05 (0.12) | 3.01 (0.09) | 0.17 | 0.86 | 3.15 (0.1) | 3.1 (0.09) | 3.07 (0.13) | 3.01 (0.08) | 0.50 | 0.97 |
| 10% slowest RT (ms)b | 378.55 (16.13) | 381.72 (15.04) | 401.86 (24.9) | 414.38 (18.56) | 0.22 | 0.85 | 377.96 (20.23) | 382.77 (15.93) | 406.02 (30.91) | 418.26 (16.84) | 0.80 | 0.47 |
| 10% fastest speed (1/RT)b | 3.53 (0.09) | 3.47 (0.10) | 3.51 (0.10) | 3.47 (0.08) | 0.029* | 0.73 | 3.51 (0.09) | 3.48 (0.08) | 3.52 (0.11) | 3.46 (0.08) | 0.77 | 0.88 |
Mood was assessed by the “Mehrdimensionaler Befindlichkeitsfragebogen” (MDBF). Sleepiness was assessed by the Karolinska Sleepiness Scale (KSS). PVT refers to a mobile version of the psychomotor vigilance task (10 min duration) to assess reaction time (RT). Cumulative link mixed model for ordinal data was used for all variables marked with a. Robust linear mixed models were performed to compare Sham to Verum nights for all interval scaled variables marked with b. P-value of factor Condition (cond, Sham vs Verum) and the interaction of condition and responder (resp, weak vs. strong) for each approach is reported in the statistics columns. Significant and trend-level p-values are marked with an asterisk (*).