Table 5.
Personalized antibiogram sensitivity analysis with and without inverse probability weights: Pip-Tazo = piperacillin/tazobactam.
| Antibiotic selection | Original classifiers | Sensitivity analysis | |
|---|---|---|---|
| AUROC | AUROC | AUROCIPW | |
| Vancomycin | 0.72 [0.68, 0.75] | 0.74 [0.71, 0.76] | 0.75 [0.72, 0.77] |
| Ampicillin | 0.62 [0.59, 0.65] | 0.69 [0.66, 0.71] | 0.69 [0.66, 0.71] |
| Cefazolin | 0.67 [0.64, 0.70] | 0.71 [0.68, 0.73] | 0.70 [0.67, 0.73] |
| Ceftriaxone | 0.69 [0.66, 0.72] | 0.72 [0.69, 0.75] | 0.72 [0.69, 0.74] |
| Cefepime | 0.65 [0.61, 0.69] | 0.64 [0.60, 0.68] | 0.62 [0.58, 0.66] |
| Pip-Tazo | 0.64 [0.59, 0.69] | 0.65 [0.59, 0.70] | 0.62 [0.56, 0.68] |
| Ciprofloxacin | 0.61 [0.58, 0.64] | 0.64 [0.62, 0.68] | 0.64 [0.61, 0.67] |
| Meropenem | 0.69 [0.65, 0.72] | 0.71 [0.68, 0.74] | 0.70 [0.67, 0.74] |
| Vancomycin + Meropenem | 0.73 [0.65, 0.81] | 0.76 [0.67, 0.84] | 0.74 [0.65, 0.84] |
| Vancomycin + Pip-Tazo | 0.70 [0.62, 0.77] | 0.71 [0.63, 0.78] | 0.70 [0.62, 0.78] |
| Vancomycin + Cefepime | 0.70 [0.62, 0.78] | 0.68 [0.60, 0.77] | 0.67 [0.59, 0.76] |
| Vancomycin + Ceftriaxone | 0.67 [0.63, 0.71] | 0.71 [0.68, 0.75] | 0.70 [0.66, 0.74] |