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. 2021 Nov 30;1:52. doi: 10.1038/s43856-021-00053-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Networks of isolates with ≤15 core genome SNPs. Each node represents one of 46 index isolates, and are color coded by MLST, shaped according to whether associated with IDU-BSI (circle) or non-IDU BSI (diamond), and labeled according to HCV serostatus (‘X’ denotes HCV co-infection). Edge length and width represent SNP distance between nodes. Inset, histogram depicting collective core genome SNP distances between isolate pairs obtained from separate patients (“interpatient”, blue) or from the same patient (“intrapatient”, red). For clarity only comparisons with <150 SNPs are displayed. Dotted line denotes the 15 SNP cutoff used to define clonal relationship between isolates. b–d Heat maps of BSI patients’ zip code of residence for all isolates (panel b), or for isolates included in panel a (panels c, d). In panel b, areas denoted by dashed or gray lines are magnified in panels c and d, respectively. e Odds ratio comparting the characteristics between isolates included in panel a (“clustered) and all other isolates in the cohort (“non-clustered”). MA, methamphetamine.