Table 1.
Demographics of index isolates included for whole-genome sequencing.
| Non-IDU patients, N = 91 | PWID, N = 154 | P | |
|---|---|---|---|
| Demographics | |||
| Age (mean, SD) | 58 ± 14 | 38 ± 10 | <0.001 |
| Female | 34 (37.4%) | 77 (50%) | 0.045 |
| Homeless | 0 (0.0%) | 12 (7.8%) | <0.001 |
| Discharged AMA | 0 (0.0%) | 43 (27.9%) | <0.001 |
| Substance use patterns | |||
| Opioid use (fentanyl or heroin) | 0 (0.0%) | 142 (92.2%) | <0.001 |
| Methamphetamine use | 0 (0.0%) | 48 (31.1%) | <0.001 |
| Comorbidities | |||
| Hepatitis B virus infection | 0 (0.0%) | 6 (3.9%) | 0.017 |
| Hepatitis C virus infection | 1 (1.1%) | 95 (61.7%) | <0.001 |
| HIV Infection | 0 (0.0 %) | 10 (6.5%) | 0.002 |
| Elixhauser comorbidities (mean, SD) | 9.0 (3.4) | 8.6 (3.9) | 0.484 |
| Clinical syndromes caused by Isolate | |||
| Infective endocarditis | 21 (23.0%) | 99 (64.3%) | <0.001 |
| Osteomyelitis | 17 (18.6%) | 33 (21.4%) | 0.576 |
| Septic arthritis | 10 (10.9%) | 27 (17.5%) | 0.149 |
| Necrotizing skin and soft tissue infection | 6 (6.6%) | 22 (14.2%) | 0.054 |
| Isolated bacteremia | 46 (50.5%) | 15 (9.7%) | <0.001 |
| S. aureus infection characteristics | |||
| Hospital Day of S. aureus Isolation for WGS (mean day, SE) | 1 ± 0.2 | 1 ± 0.3 | 0.641 |
| Duration of bacteremia (mean days, SE) | 3 ± 0.3 | 4 ± 0.3 | 0.122 |
| Central line associated bacteremia | 38 (41.8%) | 1 (0.6%) | <0.001 |
| Outcomes | |||
| 1 year Mortality | 27 (29.7%) | 22 (14.3%) | 0.082 |
AMA against medical advice, HIV human immunodeficiency virus, IDU injection drug use, PWID person who injects drugs, SD standard deviation, SE standard error, WGS whole-genome sequencing.