Figure 2.

(A) Deuterium uptake at pulse times in D₂O is plotted across a range of pH. (B) Exchange rates as a function of pH show the transition point from the EX2 to and EX1 exchange regime. Above pH 11, the exchange reaches the EX1 limit where k_ch ≫ k_op and the rate is entirely governed by the opening rate of the amide. Reproduced with permission from ref (4). Copyright 2006 American Chemical Society.