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Changes observed in the SARS-CoV-2 spike glycoprotein upon receptor binding. Beyond the stabilization seen at the receptor binding domain, there are also large changes observed within the furin cleavage site (672–690) and the stalk region (1175–1188). The long-range changes implicate the spike shifting to a primed state upon receptor binding, which leads to the activation of the protein to initiate membrane fusion. Figure adapted from ref (558).
