Solvent screening for HDA reaction.

Entry	Solvent	Time (h)	Yielda (%)	drb	Eec (%)
1	Toluene	48	86	80 20	92
2	Benzene	48	60	78 22	90
3	Xylene	48	73	77 23	88
4	Cyclohexane	48	66	74 26	89
5	Hexane	48	trace	—	—
6	Et2O	48	55	78 22	90
7	iPr2O	48	68	77 23	89
8	THF	48	40	79 21	82
9	CH2Cl2	48	74	79 21	90
10	CHCl3	48	34	84 16	92
11	C2H4Cl2	48	75	77 23	88
12	CH3CN	48	70	75 25	88
13	MeOH	48	38	68 32	83
14	Toluene	24	73	79 21	90
15	Toluene	72	86	78 22	86
16	Toluene	96	78	78 22	86
17	Neat	24	87	71 29	86
18	Neat	48	75	68 32	82

^aIsolated yield.

^bDiastereoselectivity (dr) was determined by ¹HNMR of the crude reaction mixture (major diastereomer: 8a).

^cThe ee value were determined by HPLC (Daicel chiralpak IB column).