Synergistic activity assays on MRSA.
| Compounds | MIC alone (μM) | MIC combination (μM) | FICI | Mode of action | |||
|---|---|---|---|---|---|---|---|
| A | B | A | B | A | B | ||
| 2a + ofloxacin | 6.25 | 1.25 | 3.12 | 0.04 | 0.53 | Additive | |
| 2e + ofloxacin | 1.56 | 1.25 | 0.39 | 0.04 | 0.28 | Synergy | |
| 2j + ofloxacin | 1.56 | 1.25 | 0.78 | 0.04 | 0.53 | Additive | |
| 2a + cefoxitin | 6.25 | 50.00 | 3.12 | 1.56 | 0.53 | Additive | |
| 2e + cefoxitin | 1.56 | 50.00 | 0.78 | 1.56 | 0.53 | Additive | |
| 2j + cefoxitin | 1.56 | 50.00 | 0.78 | 1.56 | 0.53 | Additive | |
| 2a + linezolid | 6.25 | 7.50 | 3.12 | 0.47 | 0.56 | Additive | |
| 2e + linezolid | 1.56 | 7.50 | 0.78 | 0.47 | 0.56 | Additive | |
| 2j + linezolid | 1.56 | 7.50 | 0.78 | 1.90 | 0.75 | Additive | |