FIGURE 3.

Convergence of microRNAs (miRNAs) reported as differentially expressed in three mouse model studies (Stark et al., 2008; Earls et al., 2012; Chun et al., 2017) and two human induced pluripotent stem cell models (Zhao et al., 2015; Toyoshima et al., 2016) of the 22q11.2 deletion. Collectively, 156 miRNAs were reported as differentially expressed (using various criteria), of which 122 (78.2%) were downregulated, 40 (25.6%) upregulated, and 6 (3.8%) up-or down-regulated in different studies. The only miRNA downregulated in all five studies was miR-185-5p, a conserved miRNA located within the proximal 22q11.2 deletion region (Guna et al., 2015). miRNAs with targets that were found to be overlapped by one or more rare genome-wide CNVs in significantly more individuals with 22q11.2 deletion syndrome in the schizophrenia than non-psychotic group in the current study are shown with a black line connecting to the studies reporting differential miRNA expression. ↑, increased expression; ↓, decreased expression.