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. 2022 Apr 26;2022:2870389. doi: 10.1155/2022/2870389

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Copyright © 2022 Jessica Ramirez et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Changes in immunolocalization of IL-16 in human ovaries during aging. (a) Section of a premenopausal ovary showing few immunopositive IL-16-expressing cells in ovarian stroma. (b) Section of an ovary from a subject at early stage of menopause. Compared with premenopausal, more immunopositive IL-16-expressing cells are seen in the stroma. (c) Section of an ovary from a subject at late stage of postmenopause. Many immunopositive IL-16-expressing cells are localized in the stroma. (d) Section of a premenopausal ovary showing a few IL-16-expressing cells in ovarian surface epithelial (OSE) layer. (e) Section of an ovary from a subject at late menopausal stage showing IL-16 expression by the epithelial cells (EC) in a cortical inclusion cyst (CIC) in ovarian stroma. (f) Section of an ovary from a subject at late menopausal stage showing IL-16 expression by cells of stromal invagination (INV). Compared with OSE and CIC, more IL-expressing cells are seen in the epithelial cells (EC) in INV. S: stroma. Magnification = 40×.