Figure 7.

Changes in immunolocalization of macrophages in human ovaries during aging. (a) Section of a premenopausal ovary showing few immunopositive macrophages in ovarian stroma. (b) Section of an ovary from a subject at early stage of menopause. Compared with premenopausal, more macrophages are seen in the stroma. (c) Section of an ovary from a subject at late stage of menopause. Many macrophages are seen in the stroma. (d) Section of a premenopausal ovary showing a few macrophages in ovarian surface epithelial (OSE) layer. (e) Section of an ovary from a subject at late postmenopausal stage showing IL-16 expression by the epithelial cells (EC) in a cortical inclusion cyst (CIC) in ovarian stroma. (f) Section of an ovary from a subject at late menopausal stage showing macrophages localized in the stromal invagination (INV). S: stroma. 40×: magnifications. Arrows indicate examples of immunopositive macrophages.