Figure 8.
Changes in the frequency of macrophages in human ovaries during aging. (a) Frequency of macrophages in the ovarian stroma in premenopausal and postmenopausal ovaries. Compared with premenopausal, the frequency of macrophages was significantly higher (P < 0.001) in subjects at early stage of menopause (55-59 years old) and increased further in subjects at late stage of menopause (60-85 years old). (b) Population of macrophages in cortical inclusion cysts (CICs) and stromal invaginations (INVs) in menopausal ovaries. Compared with CIC, the frequency of macrophages was significantly higher in INVs (P < 0.0001). y-axis shows mean ± SEM of macrophages in 20,000 μm2 area of the tissue, and bars with different letters are significantly different. Details of statistical analysis are mentioned in materials and method section of the text.