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. 2022 Apr 15;9:841568. doi: 10.3389/fmed.2022.841568

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Copyright © 2022 Xu, Chen, Niu, Xing, Yang, Yin, Guo, Zhang, Qiu and Han.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of GRIPs. (A) The co-expression network of pyroptosis-related genes and inflammation-related genes. Oval: pyroptosis genes; horn: inflammatory genes. (B) CM had higher PCA pyroptosis scores than normal samples. (C) Visualization of high and low PCA pyroptosis scores. (D) Kaplan-Meier analysis showed that patients with high PCA pyroptosis scores had a higher survival probability. (E) CM had a higher GSVA pyroptosis score than normal samples. (F) Kaplan-Meier analysis showed that patients with high GSVA pyroptosis scores had a higher survival probability. (G–J) WGCNA identified pyroptotic inflammatory modules (ME blue and ME turquoise) based on the PCA and GSVA pyroptosis scores. (K) A Venn diagram illustrates that the co-expression network analysis and WGCNA have 185 overlapped genes, which are candidate GRIPs for constructing gene signature.