Figure 6.

Environmental enrichment restores changes in mEPSC frequency induced by perinatal fentanyl exposure. A, Representative traces of mEPSCs. B, Grouped data of the averaged events from each neuron and animal indicating that mEPSC frequency is higher after environmental enrichment, compared with controls. C, Cumulative probability curves of the frequency suggest perinatal fentanyl exposure results in increased mEPSC frequency, and that raising fentanyl-exposed mice with environmental enrichment reverses this increase. Enrichment also increased mEPSC frequency of vehicle control mice independent of perinatal fentanyl exposure. D, E, There were no differences in mEPSC amplitudes. n = 6–8 mice/group, 1–2 neurons/mouse. Data depict means, and 95% confidence intervals.