Table 2.
Factors affecting overall response rate and disease control rate after treatment of non-small cell lung cancer patients
| Factor/variable | Subgroup | n | ORR (%) | P | DCR (%) | P |
|---|---|---|---|---|---|---|
| Age (years) | ≤60 | 122 | 54.9 | 0.937 | 68.8 | 0.291 |
| >60 | 101 | 55.4 | 75.2 | |||
| Sex | Male | 166 | 53.1 | 0.272 | 68.7 | 0.082 |
| Female | 57 | 61.4 | 80.7 | |||
| Education | Up to primary level | 84 | 51.2 | 0.289 | 65.5 | 0.121 |
| Above primary level | 107 | 58.9 | 75.7 | |||
| Pathology | SCC | 55 | 56.4 | 0.274 | 70.9 | 0.316 |
| ADC | 131 | 58.0 | 74.8 | |||
| NSCLC (NOS) | 37 | 43.2 | 62.2 | |||
| ECOG | 0,1 | 140 | 56.4 | 0.442 | 75.0 | 0.041 |
| 2,3,4 | 67 | 50.7 | 61.2 | |||
| Smoking | Never smoker | 82 | 67.1 | 0.005 | 85.4 | 0.001 |
| Chronic smoker | 127 | 47.2 | 63.8 | |||
| Treatment | Chemotherapy | 183 | 50.8 | 0.023 | 69.4 | 0.177 |
| EGFR inhibitors | 30 | 76.7 | 86.7 | |||
| ALK inhibitors | 8 | 75.0 | 75.0 | |||
| Compassionate based oral TKI therapy | 2 | 50.0 | 50.0 |
ORR: Overall response rate, DCR: Disease control rate, SCC: Squamous cell carcinoma, ADC: Adenocarcinoma, NSCLC: Non-small cell lung cancer, NOS: Not otherwise specified, ECOG: Eastern Cooperative oncology group, EGFR: Epidermal growth factor receptor, ALK: Anaplastic lymphoma receptor tyrosine kinase, TKI: Tyrosine kinase inhibitors