Table 2. Peptides representative for major presentable regions of Spike.

15aa peptides from the center of peaks having at least 5 consecutive peptides with MEDi-MA scores above the 85^th percentile are shown. Sequences overlapping at least 9aa with the minimum sequences of presented peptide clusters identified by Knierman et al. (25) are marked by an asterisk. Peptides overlapping at least 9aa with T cell reactive peptides identified by Peng et al. (13) and Nelde et al. (14) are highlighted in bold.

Position	DRB10701	Position	DRB10404	Position	DRB11501	Position	DPA10202B10501
8	LPLVSSQCVNLTTRT	7	LLPLVSSQCVNLTTR	59	FSNVTWFHAIHVSGT	40	DKVFRSSVLHSTQDL*
27	AYTNSFTRGVYYPDK*	62	VTWFHAIHVSGTNGT	237	RFQTLLALHRSYLTP*	50	STQDLFLPFFSNVTW*
42	VFRSSVLHSTQDLFL*	232	GINITRFQTLLALHR*	302	TLKSFTVEKGIYQTS*	70	VSGTNGTKRFDNPVL
60	SNVTWFHAIHVSGTN	402	IRGDEVRQIAPGQTG*	309	EKGIYQTSNFRVQPT*	75	GTKRFDNPVLPFNDG
111	DSKTQSLLIVNNATN	513	LSFELLHAPATVCGP*	402	IRGDEVRQIAPGQTG*	80	DNPVLPFNDGVYFAS
202	KIYSKHTPINLVRDL*	678	TNSPRRARSVASQSI	433	VIAWNSNNLDSKVGG*	106	FGTTLDSKTQSLLIV
230	PIGINITRFQTLLAL	683	RARSVASQSIIAYTM	470	TEIYQAGSTPCNGVE*	111	DSKTQSLLIVNNATN
239	QTLLALHRSYLTPGD*	688	ASQSIIAYTMSLGAE*	631	PTWRVYSTGSNVFQT*	201	FKIYSKHTPINLVRD*
309	EKGIYQTSNFRVQPT*	854	KFNGLTVLPPLLTDE*	677	QTNSPRRARSVASQS*	230	PIGINITRFQTLLAL
314	QTSNFRVQPTESIVR*	866	TDEMIAQYTSALLAG*	682	RRARSVASQSIIAYT	235	ITRFQTLLALHRSYL*
490	FPLQSYGFQPTNGVG*	919	NQKLIANQFNSAIGK*	687	VASQSIIAYTMSLGA*	495	YGFQPTNGVGYQPYR
639	GSNVFQTRAGCLIGA*	931	IGKIQDSLSSTASAL*	692	IIAYTMSLGAENSVA	551	VLTESNKKFLPFQQF*
679	NSPRRARSVASQSII*	936	DSLSSTASALGKLQD*	752	LLLQYGSFCTQLNRA	556	NKKFLPFQQFGRDIA*
684	ARSVASQSIIAYTMS	952	VNQNAQALNTLVKQL*	784	QVKQIYKTPPIKDFG	680	SPRRARSVASQSIIA*
689	SQSIIAYTMSLGAEN*	957	QALNTLVKQLSSNFG	856	NGLTVLPPLLTDEMI	704	SVAYSNNSIAIPTNF
694	AYTMSLGAENSVAYS	962	LVKQLSSNFGAISSV*	866	TDEMIAQYTSALLAG*	782	FAQVKQIYKTPPIKD*
714	IPTNFTISVTTEILP	982	SRLDKVEAEVQIDRL*	899	AMQMAYRFNGIGVTQ*	812	PSKRSFIEDLLFNKV*
782	FAQVKQIYKTPPIKD	1016	AEIRASANLAATKMS*	913	QNVLYENQKLIANQF	871	AQYTSALLAGTITSG*
869	MIAQYTSALLAGTIT*	1063	LHVTYVPAQEKNFTT	918	ENQKLIANQFNSAIG*	918	ENQKLIANQFNSAIG*
880	GTITSGWTFGAGAAL	1170	SGINASVVNIQKEID*	961	TLVKQLSSNFGAISS*	928	NSAIGKIQDSLSSTA*
885	GWTFGAGAALQIPFA			997	ITGRLQSLQTYVTQQ	960	NTLVKQLSSNFGAIS*
896	IPFAMQMAYRFNGIG*			1002	QSLQTYVTQQLIRAA	1014	RAAEIRASANLAATK*
1008	VTQQLIRAAEIRASA*			1007	YVTQQLIRAAEIRAS*	1019	RASANLAATKMSECV
1013	IRAAEIRASANLAAT*			1012	LIRAAEIRASANLAA*	1040	VDFCGKGYHLMSFPQ
1070	AQEKNFTTAPAICHD			1017	EIRASANLAATKMSE*	1045	KGYHLMSFPQSAPHG
						1066	TYVPAQEKNFTTAPA
						1071	QEKNFTTAPAICHDG
						1088	HFPREGVFVSNGTHW
						1134	NNTVYDPLQPELDSF*