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. 2022 Apr 29;8(17):eabm6210. doi: 10.1126/sciadv.abm6210

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Fig. 2. — HTLV-1 integration site and random sites were mapped with respect to DHS, and histone marks were mapped by the ENCODE project using central memory T cells. (A) Integration sites were enriched within 10 kb of a DHS. In each analysis, integration site frequency is compared to a random distribution. (B and C) The mean density of each of the four histone marks flanking the integration sites was calculated in discrete windows upstream and downstream across all integration sites from each dataset, either (B) 1-kb windows, up to 1 Mb from the integration site, or (C) 100-bp windows, up to 100 kb from the integration site. Ln(fold change from random) is shown. Dashed line denotes 100 kb upstream or downstream.