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. 2022 Apr 29;8(17):eabm6210. doi: 10.1126/sciadv.abm6210

Fig. 4. Preferential survival in vivo of infected T cell clones whose provirus lies near the nuclear lamina and distant from nuclear speckles.

Fig. 4.

Data on two mid-sized chromosomes (11 and 12) are shown; data on all chromosomes are shown in figs. S6 to S10. In each panel, the TSA-seq data on lamin A/C and SON from Chen et al. (19) are plotted against Ln(integration site frequency, F). (A) HTLV-1 integration site frequency in vivo and in vitro. (B) The HTLV-1 clone survival index CSIHTLV − 1 [Ln(Fin vivo/Fin vitro)] closely tracks the lamin A/C TSA-seq signal. (C) HIV-1 clone survival index, CSIHIV − 1.