Examples of combining a chemotherapeutic agent with a phytochemical.

Phytochemicals	Therapeutic agents	Delivery system	BCSCs targeting strategy	Combination strategy
Curcumin	Paclitaxel	PLGA based nanoparticle83	Active targeting (CD44)	Co-encapsulation
	Paclitaxel	Polymeric micelle; PEG-benzoic imine-poly(g-benzyl-laspartate)-b-poly(1-vinylimidazole) triblock copolymer84	Passive targeting AND pH-sensitive	Co-encapsulation
	Paclitaxel	Nano-egg: oligosaccharides of hyaluronan (oHA)-histidine-menthone 1,2-glycerol ketal micelle with inorganic calcium and phosphate ions108	Active targeting (CD44) AND pH-sensitive	Co-encapsulation
	Doxorubicin	Polymeric nanoparticle: monomethoxy-PEG-b-PLGA-b-P (l-glutamic acid) polymer66	Passive targeting AND pH-sensitive	Co-encapsulation
	GANT 61	Polymeric nanoparticles: poly lactic-co-glycolic acid based86	Passive targeting	Co-encapsulation
	Icariin	Polymeric micelles: polymer oligomeric HA-hydrazone-folic acid-biotin85	Active targeting (CD44) and pH-sensitive	Co-encapsulation
All-trans retinoic acid	Vinorelbine	Liposomes74	Passive targeting	Nano + Nano
	Doxorubicin	PEG-block-polylactide based nanoparticle47	Passive targeting	Co-encapsulation
Cyclopamine	Doxorubicin	PLGA nanoparticle55	Active targeting (CD44) and redox-sensitive	Co-encapsulation